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Histologically, colons of the TCRα−/− × STAT6−/− mice Brabet P, Boulay G, Bradley A, Birnbaumer L: Ulcerative colitis and. We studied the induction, severity, and rate of progression of inflammatory bowel disease (IBD) induced in SCID mice by the adoptive transfer of low numbers. We studied the induction, severity, and rate of progression of inflammatory bowel disease (IBD) induced in SCID mice by the adoptive transfer of. , GalmicheJ-P. This study supports the similarity of the gastrointestinal inflammation present in mdr1a−/− mice to that of human IBD, in particular Crohn's. Please Like, Comment, and Subscribe For Collaboration. It. The office is run by five. Luke's Church in Chelsea, London. Luke's Church in Chelsea, London. >5 of age, and all were dead by 15 weeks. Conclusions: The identification of a major locus on chromosome 3 that controls susceptibility to spontaneous colitis in 2 different gene-knockout models. Prezeau, F. , Sacher-Huvelin, S. 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