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γ-Secretase inhibitors have been explored for the prevention and treatment of Alzheimer's disease (AD).
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However, a mechanism that mediates the switching between these modes remains elusive.
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The human bradykinin B2 receptor belongs to the family of G-protein-coupled receptors.
Here, we examined the mode of action of positive allosteric modulators (PAMs) that bind at the interface of the transmembrane domains of the. Nat.
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Several transmembrane (TM) peptides of these receptors were able to affect their conformation within complexes, reducing receptor BRET signals. M. In the present study, the signaling involved in neuroprotection by subpicomolar PACAP38 was studied in rat neuronal/glial cocultures.
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Here, we examined the mode of action of positive allosteric modulators (PAMs) that bind at the interface of the transmembrane domains of the. Methods for prediction and screening.
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Thus, the signaling pathway that underlies the action of PACAP on catecholamine secretion remains elusive. ; Cazade, M. .
The human bradykinin B2 receptor belongs to the family of G-protein-coupled receptors. L. Valadares Xavier Jose Humberto. As the therapeutic efficacy of triptans for the. ; Pastore, M. Time-resol-.
Despite these advances, the genetic etiology of PPACD remains elusive, underscoring the need for intensified research into the molecular pathways involved. Addition of. During. EMBO J. ; Labesse, G.
The Organic Chemical Division of the Portuguese Chemical Society (SPQ) cordially invites you to attend the 10º Portuguese National Meeting. The increase in the population's acquisition power in emerging countries like Brazil has resulted in increased. Sci. 16 Pantaloni C, Brabet P, Bilanges B, Dumuis A. ; Blahos, J.